Dr Rebecca Devine
Research Fellow
Antimicrobial resistance is one of the biggest threats to modern medicine, therefore discovering new bioactive molecules is vital.
Rebecca is interested in the how antibiotic biosynthesis is regulated in the ‘talented’ strain, Streptomyces formicae. She is using CRISPR/Cas9 gene editing to mine this strain for bioactive compounds and understand more about the genes that control their production. Rebecca is also interested in the mode of action of newly isolated compounds in a variety of clinically relevant microorganisms.
Selected Publications
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Qin Z., Devine R., Hutchings M. I., Wilkinson B. (2019)A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis.Nature communications (10)Publisher's version: 2041-1723
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Qin Z,Devine R,Booth TJ,Farrar EH,Grayson MN,Hutchings MI,Wilkinson B (2020)Formicamycin biosynthesis involves a unique reductive ring contractionChemical SciencePublisher's version: 2041-6520 (print)
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Devine R,McDonald H,Qin Z,Arnold C,Noble K,Chandra G,Wilkinson B,Hutchings M (2021)Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds.Cell chemical biologyPublisher's version: 2451-9448